The long expected bout between Yoshihiro Akiyama and Wanderlei Silva will not take place at this event. Instead, Silva will face Michael Bisping.

A bout between Nate Marquardt and Chael Sonnen which was expected to take place on this card was moved to UFC 109. A bout between Keith Jardine and Rich Franklin was being discussed. Jardine will instead fight the Ultimate Fighter 8 Winner Ryan Bader.

Chris Lytle was expected to face Dong Hyun Kim, but Kim has been forced off the card with an injury. Brian Foster will step in to fight Lytle.

The bout between Elvis Sinosic and Chris Haseman was due to be the first ever all-Australian bout to take place in the UFC. However, on 18th February, a shoulder injury forced Elvis Sinosic out of his fight with Chris Haseman. Additionally, Ben Rothwell was sidelined by an illness, leading to Australian veteran Anthony Perosh stepping in to face Mirko Cro Cop.

Tickets for the event sold out on the first day they were available to the general public. It was the second fastest sellout of an event in the history of the UFC, behind UFC 83. UFC 110 will be aired live on Australian free-to-air sports channel ONE HD.

Official Fight Card

Preliminary Card

Light Heavyweight Bout:  James Te-Huna vs.  Igor Pokrajac
Middleweight Bout:  C.B. Dollaway vs.  Goran Reljic
Welterweight Bout:  Chris Lytle vs.  Brian Foster
Light Heavyweight Bout:  Stephan Bonnar vs.  Krzysztof Soszynski

Main Card

Heavyweight Bout:  Mirko Filipović vs.  Anthony Perosh
Light Heavyweight Bout:  Keith Jardine vs.  Ryan Bader
Lightweight Bout:  Joe Stevenson vs.  George Sotiropoulos
Middleweight Bout:  Wanderlei Silva vs.  Michael Bisping
Heavyweight Bout:  Antonio Rodrigo Nogueira vs.  Cain Velasquez